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Studies indicate that diminished VEGF expression precipitates neurodegeneration by compromising neural tissue perfusion, thus exacerbating neuronal vulnerability to ischemic insults and metabolic imbalances (Oosthuyse et al
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Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, Wan J, et al
ARV-471, which selectively degrades estrogen receptor , is in phase I/II trials for advanced breast cancer (NCT05573555)
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