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GLP-1 medicines are designed to act like this hormone while lasting longer in the body
Chronic oxidative stress thus contributes to insulin resistance development (Schattenberg et al
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These differences are usually small and dont meaningfully impact treatment
Finally, the study was conducted in Caucasian adults, limiting the findings generalizability to more diverse populations
However, there is still a significant difference between the WL that can be achieved with bariatric surgery and the currently approved obesity pharmacotherapies and there is heterogeneity in treatment responses with GLP-1 RA (for example people with T2D may achieve less WL compared to those without diabetes in clinical trials, despite similar lifestyle interventions) [13, 14]
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