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Weight loss contributes to the loss of significant weight loss, resulting in: Limited Caloric Burn: Muscle burns greater calories than fat when energy is stored (i.e
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GLP-1 medications work by mimicking the actions of your natural GLP-1, binding to cells throughout your body that have GLP-1 receptors, and ultimately lowering blood sugar
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A 2023 review in The Lancet Diabetes & Endocrinology described these adaptations as "the biological basis for weight regain" and noted that pharmacotherapy must overcome these signals continuously to maintain weight loss 10