52 For example, during ischemic injury, the heart experiences an overload of misfolded proteins due to oxidative stress and energy depletion
Several practical factors may explain fatigue during GLP-1 therapy: Reduced food intake due to appetite suppression can lead to lower energy consumption Gastrointestinal side effects like nausea can be physically draining Adaptation to metabolic changes as your body adjusts to the medication For people with diabetes who take insulin or sulfonylureas (like gliclazide) alongside GLP-1 medications, low blood glucose (hypoglycaemia) may cause fatigue
If the decision to withhold GLP-1RAs is indicated, the duration of cessation should follow the guidance of the ASA: on the day of the procedure for daily formulations, and one week prior for weekly formulations [20, 21]
Back Secher, A, Jelsing, J, Baquero, et al (2014) 'The arcuate nucleus mediates GLP- 1RA liraglutide- dependent weight loss', Journal Clinical Investigation , 124, 447388
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