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Several studies have identified various sources of ROS and RNS in IBD, including neutrophils, macrophages, and inflamed intestinal tissue ( 2 Mechanism of oxidative stress in IBD While the precise mechanisms responsible for the development of IBD remain unclear, it is widely accepted that multiple factors contribute to its etiology, including overproduction of ROS, damage to biomolecules, mitochondrial dysfunction, recruitment of immune cells, impaired antioxidant defense system, and the activation of inflammatory pathways ( Figure 1 )

10.1016/0163-7258(91)90076-X

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Changes in expression levels of these marker proteins could imbalance ROS levels, leading to a gradual reduction in melanocyte protection and viability over time leading to hair greying

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