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However, humans and monkeys express lower levels of the GLP-1 receptor in thyroid C-cells than rodents, and GLP-1 receptor agonists are unlikely to stimulate adenylate cyclase or increase calcitonin release in primates [65]
However, in a transgenic mouse model, persistently high GIP levels resulted in improvement of -cell function, promote insulin sensitivity and gene transcription, glucose tolerance, and reduction in weight gain (15)
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Presented for research literature review only Vidal-Lin L et al
New insights into acute pancreatitis
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