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NRF2 is reported to have suppressive effects on the lipogenic pathway via inhibiting the activity of LXR 64,70 , a transcription factor that supports lipid synthesis
Both medications are also approved in different formulations and doses for type 2 diabetes, and those doses are not the same as the obesity versions
Combined use should always follow clinical assessment and should not replace investigation of underlying causes
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Specifically, semaglutide works by: Slowing down digestion, so you feel full sooner Regulating the release of insulin and glucagon after you eat to keep your blood sugar levels stable Sending signals to your brain telling it that youre full Together, these effects help stabilize blood sugar levels and reduce appetite, making semaglutide an effective treatment for type 2 diabetes, obesity, and more
