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Mandibular melanotic neuroectodermal tumor of infancy: a role for neoadjuvant chemotherapy
RBP-J then transcriptionally enhances TRIM59 expression, forming a feedforward loop that drives gemcitabine resistance
What they did: They transected the quadriceps (front thigh) of rats and divided them into three groups: Control, no drugs Dexamethasone, a potent corticosteroid that is known to impair healing Dexamethasone + BPC-157 What they found: Dexamethasone group: 50 % worse healing than control (confirmed negative effect of steroids) Dexamethasone + BPC-157 group: healing at the level of controls without steroids Why it matters: This is a highly clinically relevant finding
10.3171/2023.8.Spine23427 40
Pasalic D, Betancourt-Cuellar SL, Taku N, Ludmir EB, Lu Y, Allen PK, Tang C, Antonoff MB, Fuller CD, Rosenthal DI, Morrison WH, Phan J, Garden AS, Welsh JW, Chang JY, Liao Z, Erasmus JJ, Nguyen QN
Per NICE guidance (NG12), patients with obstructive jaundice should be referred urgently via a suspected cancer pathway
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