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Physiology & Behavior, 92 (4), 575-582

In cultured human islets and in C57BL/6 mice, both aGLP1 and aGLP1-E2 enhanced glucose-stimulated insulin secretion (GSIS) compared to vehicle and iGLP1-E2 without superior efficacy of aGLP1-E2 compared to GLP-1 alone

Moreover, SCFAs such as acetate can remodel macrophage glycolysis, activate the hypoxia-inducible factor 1 (HIF-1) axis and NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, thereby increasing interleukin-1 (IL-1) and nitric oxide production and enhancing pulmonary innate immunity (Machado et al., 2022)

[19] Compared to placebo, supplemental carnitine improved sperm motility by 7.84% and morphology by 4.91%, but did not affect sperm concentration

Sachdev, E., Tabatabai, R., Roy, V., Rimel, B

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