Loss of EZH2 impairs this mechanism, stabilizing forks and attenuating PARPi efficacy
Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis
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At the same time, cardiologists are closely following the research and exploring treatment for certain populations
Typical for LCHAD deficiency is the increased risk for female heterozygous carriers to develop hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome and acute fatty liver of pregnancy (AFLP) [135, 136]