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The methylation of the GPx3 promoter was also observed in hepatocellular carcinoma (HCC) tissue [101] and gastric carcinoma [102], possibly leading to subsequent carcinogenesis and cancer cell progression

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Mitochondria, as the primary source of ROS in mammalian cells, are particularly vulnerable, with oxidative stress contributing to mitochondrial dysfunction, energy depletion, and cell death (Cui et al., Several studies have highlighted oxidative stress as a key factor in ME/CFS

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