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Glutathione S-transferases (GSTs) are the enzymes expressed in the cytosol, microsomes, and mitochondria and catalyze glutathione conjugation to electrophilic compounds, not only produced from exogenous xenobiotics by biotransformation but also arise from endogenous substances
Either way, the practical implication is similar, and it is arguably the most consequential consideration for anyone planning future work: on the brain-access hypothesis, novel dual GLP-1/GIP agonists engineered specifically for brain entry would be more rational next candidates to test than repurposed diabetes drugs chosen for market availability
All peptides except A 16 were N-terminally acetylated and C-terminally amidated
Tolerance and response: a provider adjusts based on how a patient actually responds over time, which no static number can anticipate
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