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10.1136/bmj.g2366 29 LiguoriV.GaioM.ZinziA.CagnottaC.RiccardiC.DocimoG.et al (2023)
Patients typically start with lower doses to minimize potential side effects
Dose-specific weight loss outcomes for tirzepatide Source: SURMOUNT-1 trial (Jastreboff et al., NEJM 2022)
MCF-10A and U-2 OS cells transduced with retroviral vectors (pBABE or pBABE-GFP-H2B) were selected with puromycin (1 g/ml)
A rare and fatal outcome : A 64-year-old with no history of pancreatitis developed a severe, fatal form of the condition after 24 doses of the lowest available tirzepatide dose (2.5 mg)
Value-based decision-making aims to capture both the efficacy and costs of interventions, ensuring that funded interventions represent good value for money
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