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In a chronic social defeat stress model in mice, 21 days of oral administration at 0.1 mg/kg corrected depressive-like behavior, restored motor activity with a therapeutic effect of 60 percent, completely recovered anhedonia, restored synaptophysin levels (74 percent therapeutic effect), and fully restored CREB levels in the hippocampus

Journal of Physiology - Paris 2009 DOI Toxicity by NSAIDs: counteraction by stable gastric pentadecapeptide BPC 157 Sikiric P, Seiwerth S, Rucman R, et al