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Note that these two documented starting doses are worlds apart in size 150 mcg versus 2.5 mg is a roughly 17-fold difference

The US Anti-Doping Agency (ADA) states that because it has not been extensively studied in humans, "no-one knows if there is a safe dose, or if there is any way to use this compound safely to treat specific medical conditions"

It upregulates PD-L1 expression in ovarian cancer cells via the mTOR signaling pathway, contributing to tumor progression [45]

Serious adverse events were rare and not dose-dependent

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2 , 8 It's less effective than metformin head-to-head, but you may find the side-effect profile more favourable