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It works differently than many currently available treatments because it targets three hormone receptors involved in metabolism and appetite regulation: GLP-1 GIP Glucagon Because of this triple-action mechanism, retatrutide has shown very promising results in early clinical trials, with some participants experiencing significant reductions in body weight

Ghosh, R

Retatrutide (LY3437943): This is a formidable research peptide, a novel agonist for three key receptors: the glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon (GCG) receptors

The science behind split dosing Split dosing is not a random idea someone came up with on a forum

Kaiser, U

Onofrj M, Fulgente T, Melchionda D, et al