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News provided by Eli Lilly and Company May 21, 2026, 06:45 ET In TRIUMPH-1, participants on 12 mg retatrutide lost an average of 70.3 lbs (28.3%) over 80 weeks with 45.3% of participants achieving 30% weight loss, a level long associated with bariatric surgery Individuals with a baseline BMI 35 who participated in a study extension continued to lose weight, and achieved up to an average of 85.0 lbs (30.3%) weight loss at 104 weeks At the 4 mg dose, reached with only a single escalation step, participants lost an average of 47.2 lbs (19.0%) at 80 weeks with a lower observed discontinuation rate due to adverse events vs

Popular sentiment and anecdotal evidence abound that these drugs are effective, but clinical research reveals just how effective they are

Chew sugar-free gum after meals or snacks to trigger saliva production

There is an urgent clinical need to explore novel therapeutic targets and strategies [2]

Q: How can I maintain my weight loss

GLP-1 Agonists: Supporting Success with Nutrition and Lifestyle Considerations (1 hour) CE/CME Course #: 25-397 This course reviews clinical evidence for glucagon-like peptide-1 (GLP-1) receptor agonists for conditions including type 2 diabetes and weight loss