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Individuals should be advised to contact their GP or diabetes specialist nurse promptly if they experience: Persistent vomiting or diarrhoea lasting more than 24 hours Inability to maintain adequate fluid intake Signs of dehydration : dizziness, reduced urine output, dark-coloured urine, dry mouth, or excessive thirst Unexplained fatigue or weakness Swelling of the ankles, feet, or face (which may indicate fluid retention or worsening kidney function) Patients with pre-existing kidney disease should be particularly vigilant and may benefit from more frequent contact with their healthcare team during treatment initiation

Advantage : Semaglutide Glycemic Control# Orforglipron : ACHIEVE-3 showed orforglipron 36 mg reduced HbA1c by 2.2% at 52 weeks, superior to oral semaglutide 14 mg (1.4% reduction)