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HRT Supports Muscle Mass Preservation: Studies show that women on hormone replacement therapy may be able to maintain significantly more lean body mass during and after menopause compared to those without hormone therapy
The 28.7% weight loss and 82% liver fat reduction could justify this designation, particularly for MASLD, which currently has limited treatment options
In 2026, prescribing guidance caught up: start at the lowest effective dose, delay escalation if weight loss exceeds 1.5 kilograms per week, track muscle mass routinely, require 1.2 to 1.6 grams of protein per kilogram daily
Semaglutide slows gastric emptying by 10% to 30%, measured by acetaminophen absorption testing in pharmacokinetic studies submitted to the FDA (FDA label, Section 12.2)
Animal studies showed that these medications could lead to thyroid tumors, including medullary thyroid carcinoma (MTC)
A planned discontinuation under medical supervision is always safer than stopping abruptly
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