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In these cases, the weight-related health risk is immediate and serious, the drugs cardiovascular and metabolic benefits are well-evidenced, and the risk-benefit calculation clearly favours pharmacological intervention

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Although the result was contrary to a previous study, which might partly result from different animal species, assessment method for osteoclast number and drug dose, the bone resorption efficiency of osteoclasts declined in this experiment, leading to decreased bone resorption overall (30)

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