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This review uniquely integrates the gastrointestinal and tumor microenvironment barriers encountered in oral chemotherapy for CRC and establishes the rationale for using nanoparticle-based drug delivery and for developing suitable nanoformulations to overcome these barriers and impart therapeutic effects
Patients must carefully consider the potential risks, benefits, and financial aspects
The compound does not appear to have carcinogenic activity in the models tested, and its interaction with tumor biology, a legitimate concern given that angiogenesis also supports tumor vascularization, has been examined in several studies without evidence of tumor promotion at physiological doses
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S., Ryan, M
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