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Sudden high-dose probiotic introduction can temporarily worsen bloating and gas as your gut flora adjusts
Subjects were followed for three years or until the outcome occurred (or administrative censoring at the end of follow-up)
Starting doses are sub-therapeutic by design, existing to allow gastrointestinal adaptation, yet some patients get appetite reduction and modest weight loss even there
However, direct comparisons require caution because: Trial lengths differed Dosing protocols differed Patient populations differed Long-term orforglipron data is still developing A 5% to 10% reduction in body weight can still produce clinically meaningful improvements in blood pressure, insulin sensitivity, mobility, and metabolic health
Venue: Where a case is filed can impact settlement size
Neither medication is significantly harder to tolerate than the other
