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Prescription agents (e.g., semaglutide) : Stronger clinical evidence, FDA-regulated, but may carry more systemic side effects
blood pressure may decrease alongside weight loss, and any cardiovascular effects should be interpreted in the context of overall trial data rather than assumed to be adverse
It works through a different mechanism than diet and exercise alone, making it valuable for people with hormonal or metabolic factors contributing to weight gain.
This helps ischemic preconditioning and decrease myocyte apoptosis
Both drugs share similar gastrointestinal side effects, and both carry boxed warnings related to thyroid cancer risk and MEN2