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An Evidence-Based Perspective Key Points GLP-1 medications are safe from a psychiatric perspective and dont increase risk of depression or suicidality These medications improve mental health-related quality of life and eating behaviors beyond their effects on weight Lower doses combined with comprehensive psychological and lifestyle support produce excellent results with minimal side effects GLP-1s reduce inflammation, which directly benefits mood and neurotransmitter function Psychiatrists are well-positioned to prescribe GLP-1s as part of integrated metabolic-psychiatric care I want to address a question that comes up constantly in psychiatric circles right now
The chart above represents a starting framework, not an immovable protocol
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When these medicines stimulate GLP-1 receptors in the stomach, they also slow gastric emptying, or how quickly food moves from your stomach to the lower intestine
Some weeks you may feel the medication working strongly, while others may feel like a plateau
For patients struggling to consume sufficient solid protein, medical-grade protein powders mixed with water or sugar-free liquids offer a practical alternative
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