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This phenomenon appears to be multifactorial, driven by increased awareness of androgen deficiency syndromes, the expanding off-label prescription of testosterone preparations, and the widespread non-medical use of anabolicandrogenic steroids (AAS) to enhance physical performance and appearance

To avoid anesthetic complications, patients may be advised to discontinue semaglutide or GLP agonists a week before surgery, or they may need to have an ultrasound to check the contents of their stomach before anesthesia is administered

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For moderate-to-severe active disease, systemic glucocorticoids may be used to reduce inflammation and periorbital edema

The reduction in TKV was attenuated and no longer significant in the semaglutide and empagliflozin groups when adjusting for changes in GFR

Future trials focused specifically on skeletal outcomes are needed to inform guidelines