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Follow the recommended dosage

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Scientists don't fully understand how these drugs work yet

Theres anecdotal concern and some research-based evidence that large creatine doses can put some stress on the kidneys and liver, but direct research into these potential effects is lacking, and long-term high-dose research has not produced adverse effects in either organ system

Moreover, given no heterogeneous treatment effects found by age, gender, or diabetes severity for GLP-1RAs versus insulin in our previous analyses [6] and limited study subjects with different patient characteristics in the present study, performing the cost-effectiveness analysis stratified by different patient demographic or clinical characteristics would be infeasible

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