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Abstract Purpose Manufacturing processes for polypeptide/protein drugs are designed to ensure robust quality, efficacy and safety

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Two practical consequences fall out of this mechanism, and both explain the shape of the protocol below

doi: 10.3389/fonc.2026.1834606 Received 19 March 2026 Revised 09 May 2026 Accepted 13 May 2026 Published 28 May 2026 Volume 16 - 2026 Edited by Fahui Liu, Xiamen University, China Reviewed by Armando Patrizio, Memorial Sloan Kettering Cancer Center, NY, United States Qiming Gong, Affiliated Hospital of Youjiang Medical University for Nationalities, China Hao Ling, Technical University of Munich, Germany Updates Copyright 2026 Kennedy, Thomas, DArcy, Odia, Kamdar, Pereira, Scarola, Miles, Frank, Taneja, Seetharamu and Mandal

It does make it a complementary adjunct rather than a foundation

If carried out as planned, these changes could make GLP-1s (and potentially other important drugs) more affordable for millions of Americans