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Nonalcoholic steatohepatitis is the fastest growing cause of hepatocellular carcinoma in liver transplant candidates

In light of recent discoveries regarding lactate-mediated Kla in tumor immunology and immunotherapy, this review provides a synthesis of the current understanding of the immunomodulatory effects of Kla and the translational landscape of Kla-targeted therapeutics

Of the 75% who report digestive side effects, symptoms extend well beyond the nausea most commonly discussed in coverage of these medications, underscoring why a one-size-fits-all approach falls short and personalized care matters: 32% nausea 26% constipation 25% bloating or gas 21% acid reflux 21% feeling uncomfortably full after eating very little 21% diarrhea 18% abdominal pain 14% loss of appetite to the point of concern 10% vomiting From Trade-Off to Solution These findings land as GLP-1 use accelerates

"GLP-1 medications have transformed weight loss medicine

Policymakers must balance the potential for long-term cost savings against immediate budget constraints

As GLP-1s become more socially acceptable, theres growing worry about misuse by people who dont meet clinical criteria for the medication