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Safety considerations Available evidence suggests that combined therapy with SGLT2 inhibitors and GLP-1 receptor agonists is generally well tolerated, with safety profiles largely consistent with those of each class individually [24, 40,41,42,43]

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Physicians in charge decided plasma sampling to measure plasma VPA concentrations, treatments and L-carnitine dose regimen, which included an intravenous 100 mg/kg loading dose followed by a maintenance dosing up to 3 g/day in 3 divided doses for 3 days (or until ICU discharge)