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Remember, small tweaks lead to massive peaks
1 9 10 But animal efficacy translating to human benefit is the exception, not the rule, in drug development
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Current DON detoxification strategies include physical, chemical, and biological approaches
10.1016/j.ejmech.2021.113155 8 ArakawaK.MaeharaS.YugeN.IshikawaM.MiyazakiY.NabaH.et al (2016)
Chronic exposure has been associated with: Liver stress Immune suppression Increased inflammatory burden (14) Trichothecenes Often associated with Stachybotrys chartarum , trichothecenes can: Inhibit protein synthesis Disrupt mucosal immunity Intensify inflammatory signaling (15) Gliotoxin Produced by certain Aspergillus species, gliotoxin has immunosuppressive effects and may impair macrophage function and immune clearance (16)
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