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Moreover, the GLP-1R knockout mice self-administered more nicotine than their wildtype counterparts (Tuesta et al., 2012)
Alvarez E, Martnez MD, Roncero I, et al
Peptone-triggered secretion of GLP-1 from murine primary colonic cultures is also abolished in the presence of CaSR antagonists and removal of extracellular calcium, though whether this effect represents the sensing of individual amino acids generated by initial protein breakdown, or the ability of small peptides to bind to the CaSR is unclear (132)
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