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Postmarketing surveillance continues, and pharmacovigilance will pick up new safety signals if they emerge
These improvements reduce the burden associated with frequent injections and make GLP-1 therapies more accessible to a broader population, such as those who may be hesitant about injectable medications
Although investigations in animals are scarce, studies among humans have suggested that GLP-1 RAs directly mitigate the development of coronary atherosclerosis through several mechanisms (Table 1)
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The TRAVERSE trial, the first large randomized controlled study on testosterone replacement therapy, demonstrated that modest testosterone doses did not increase cardiovascular event risk in men aged 45-80
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