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Current medical guidance recommends discontinuing GLP-1 medications prior to conception
Mounjaro (tirzepatide) is a dual GLP-1 and GIP receptor agonist licensed in the UK for type 2 diabetes mellitus treatment
Exendin-4 (Exenatide) mimicks GLP-1 but is much more potent in vivo following parenteral administration (28)
10.3748/wjg.v23.i25.4491 108 PucheJ
Studies reported up to 24.2% reduction in body weight over a 48-week period
Growth hormone secretagogues like MK-677 (a ghrelin receptor agonist) face the same limitation: they cant override elevated somatostatin or suppressed GHRH signaling
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