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doi: 10.1016/j.cell.2017.03.035 132

PT, Prothrombin time

Different cellular and pathological disorders including calcium imbalance, altered mitochondrial dynamics, impaired biogenesis, oxidative stress, defective mitophagy, impaired mitochondrial trafficking, and dysfunctional respiratory chain lead to the development of mitochondrial dysfunction with subsequent progression of PD due to degeneration of DNs (Fig

Increased lifespan Lifespan analysis of generations of genetically modified mice revealed an increase in the maximal lifespan of the TertKI mice by 27.48% and a 16.57% increase in median lifespan compared to WT mice

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