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It is important to underscore the fact that pioglitazone is associated with potentially serious adverse events such as fluid retention, weight gain, and increased risk of congestive heart failure, albeit in the absence of increased cardiovascular mortality [62, 63]
Other studies also showed postmenopausal women presented lower IGF-I level compared to premenopausal women of same age [6,7], which was in accordance with our study results
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