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Why is L-Glutathione reduced

(PubMed) Cristofano A, Sapere N, La Marca G, et al

Gen Comp Endocrinol 258:119133 Zeleznik AJ, Saxena D, Little-Ihrig L (2003) Protein kinase B is obligatory for follicle-stimulating hormone-induced granulosa cell differentiation

AbbVie played these games with Humira, receiving 20 years of exclusivity through these same tactics

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Conclusion: direct IV NAD+ has a real biological effect , although the mechanism is more complex than simple replenishment of the NAD+ pool (via metabolites)