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The STEP 1 extension study (Wilding et al., 2022) showed that participants regained a significant proportion of lost weight within one year of stopping semaglutide

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Endocrinology and Metabolism Clinics of North America, 31(3), 751-778

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This is not degradation

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Secondary endpoints included knee osteoarthritis pain via the WOMAC (Western Ontario and McMaster Universities Arthritis Index) subscale

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How GLP-1 Works in the Body GLP-1 is a hormone released in the gut after eating

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