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313 High expression of claudin-2, a tight junction protein, can increase the permeability of the intestinal barrier and disrupt its structure

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According to FDA guidance, compounded medications may be appropriate when a patient's medical needs cannot be met by an FDA-approved drug, or when the approved drug is not commercially available

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The investigators reported: A literature search identified four studies of SSRI use and risk for upper gastrointestinal bleeding and a further two studies of SSRI use and bleeding in general, including upper gastrointestinal bleeding