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As suggested above and in figure 1, the methionine cycle and the transsulfuration pathway influence homocysteine concentration and for this reason they are important research targets: The formation of methionine from homocysteine is essential to reduce the risk of homocysteine toxicity, conserve methionine as a substrate for protein synthesis, and produce a principle methylating agent in the form of SAM
PMID 25024695
Some patients in edge cases may still be reviewed individually
LangSFairfiedBGaoBDuanYZhangXFoutsDEet al
Bulletin of the Menninger Clinic 62, 126126.Google Scholar Auton, A, Abecasis, GR, Altshuler, DM, Durbin, RM, Bentley, DR, Chakravarti, A, Clark, AG, Donnelly, P, Eichler, EE and Flicek, P (2015) A global reference for human genetic variation
Psychoneuroendocrinology , 38(8), 12591270
