Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig
Given the specific subcellular localization of SLC7A11 and its recognized functional significance, it is not unexpected that a multitude of studies have consistently demonstrated the involvement of SLC7A11 in various neurodegenerative, ocular, and immune disorders ( It is noteworthy that SLC7A11 is prominently expressed in numerous tumors and exerts influence on tumor progression, invasion, metastasis, and unfavorable prognosis
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