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In an autocrine mechanism, SASP factors reinforce the cellular senescence of the senescent cells themselves, while in a paracrine mechanism, they are responsible for inducing senescence in surrounding cells [35]
Their effectiveness, benefits, and recommended dosage
This drug is typically used in combination with a reduced-calorie, low-fat diet and exercise program
This paper provides a definition of the mechanism of break-induced telomere synthesis at ALT-positive telomeres, and its reliance on the unique RFCPCNAPol replisome
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