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in misuse scenarios, cardiomegaly has been reported

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Effect of metformin and exenatide on pregnancy rate and pregnancy outcomes in overweight or obese infertility PCOS women: long-term follow-up of an RCT

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This selectivity translates to fewer side effects and more predictable outcomes

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additive with GLP-1 Semaglutide Established CV outcomes Tirzepatide Highest single-agent obesity efficacy Retatrutide Triple-agonist mechanism Numbers reflect published Phase 3 endpoints where available

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