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NanoBRET membrane-binding assays HEK293A WT and HEK293A G cells were transiently transfected with Nluc-hGLP-1R or Nluc-hGLP-1R + G s + G12

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Medications were unchanged for at least 4 months before and during the study

Conclusions/interpretation At current prices, use of SGLT2is, but not GLP-1 RAs, would be cost-effective when considering only their cardiovascular and kidney disease benefits for people with type 2 diabetes

The transition is smooth and the human agents are responsive