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In addition, chimeric GLP-2 whose C-terminal fragment (residues 2033) was replaced with that of GLP-1 displayed a 17-fold potency reduction in GLP-2R signaling but successfully elicited GLP-1R-mediated cAMP accumulation (Fig

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In contrast, Cagrilintides targeted amylin receptor activation focuses specifically on appetite regulation and satiety enhancement, which may provide more predictable and manageable side effect profiles

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