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Treatment of animals with excessive -amyloidosis with newly developed reversible MAO-B inhibitor KDS2010 or the potent H 2 O 2 scavenger AAD-2004 ameliorated neurodegeneration
10.1016/j.cortex.2015.08.022 Keywords VX Drug Class: Chemical Warfare Agent classified as a Nerve Agent Mechanism of Action & Effects: Routes of exposure: VX can be absorbed through the eyes or the skin of the victim As little as one drop of VX on the skin can be fatal (as compared to 1 to 10 mls of sarin or soman) The LD50 for humans is estimated to be ~10 mg Notes: Amber (honey brown) colored, tasteless & odorless, oily liquid with low volatility unless temperatures are high The V of VX signifies it very long persistence compared to sarin and soman VX decomposes at a rate of ~ 5% a month at 71 C VX-inhibited cholinesterase can be reactivated by 2-PAM for as long as 48 hours (Sidell & Groff : The reactivatibility of cholinesterase inhibited by VX and sarin in man
The potential mechanism for this effect includes the deposition of collagen through the ERK1/2 signaling pathway, re-epithelialization and glandular tissue formation [3]
Mechanistic basis of the tyramine-induced cheese reaction in patients receiving monoamine oxidase inhibitors (MAOIs)
RamanathanRRosenPWagnerASahasrabudheSWeissGLeePet al
Insani N, Kamaluddin H, Swanny S
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