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A year after stopping taking weight loss drugs such as Ozempic and Wegovy, people regain on average 60% of their lost weight but beyond this, their weight regain plateaus, with individuals managing to keep off 25% of the weight lost to treatment, say researchers at the University of Cambridge

Physiology & Behavior

JMIR Infodemiology (2025)

Michael Stubblefield: Absolutely

However, other studies involving people with early Alzheimer's or mild cognitive impairment have yielded negative results: One published last year showed no connection between semaglutide and a slowing of cognitive decline

Melanie Avalon: I'm really just excited though by the conversation because I love when I learn the actual mechanism behind something that is very common and I never really understood how it works