V., Subramaniyam, V., Pattabiraman, A
For context, diarrhoea is reported in approximately 916% of patients taking semaglutide 2.4 mg (Wegovy) according to its UK Summary of Product Characteristics (SmPC, emc), and in a broadly similar range for tirzepatide (Mounjaro) per its UK SmPC
From there, they may gradually increase your dose over time (depending on how well you tolerate the medication) until you reach a maintenance dose for weight loss
How does the Precision Peptide Genetic Test help optimize my GLP-1 timing
Summary of timing variables to experiment with Here is a quick reference table for the variables you can adjust: What the clinical trial data tells us about timing The phase 2 retatrutide trial published in the New England Journal of Medicine enrolled 338 participants and tested doses ranging from 1 mg to 12 mg over 48 weeks
Lets break down the science behind it: GLP-1 and Appetite Control One of the primary benefits of GLP-1s is how they regulate appetite