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Using this model, we now demonstrate that Trkb deletion-induced iSPN dysfunction leads to a hyperdopaminergic state in the pre-symptomatic phase, before motor dysfunction onset, reminiscent of the dopaminergic dysfunction observed in the brains of patients with HD 3,4,5

Santulli P, Borghese B, Chouzenoux S, Vaiman D, Borderie D, Streuli I, Goffinet F, de Ziegler D, Weill B, Batteux F, et al

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(PMID 538078) Quoi de neuf sur la vitamine C