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GLP-1RAs also reduce food intake by modulating appetite-regulating pathways in the brain, resulting in weight loss (Koide et al., 2025) (see Figure 1)

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Bringing new therapies to market requires companies to conduct extensive, time-consuming, and expensive studies to demonstrate long-term safety and efficacy, particularly as these drugs expand into indications such as obesity and cardiovascular risk reduction

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Prevalence, patient characteristics, and outcome