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Once nausea resolves (typically by week 6-8), most patients find semaglutide highly tolerable and continue enjoying sustained appetite suppression and steady weight loss over months

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GI Tolerability (Future) MariTide Phase 2 data showed GI side effects were predominantly mild, transient, and concentrated at the first dose, suggesting potentially better long-term GI tolerability compared to weekly incretin injections

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The protein content may exceed prescribed restrictions for chronic kidney disease patients

In the dosing conditions trial, 599 AEs were reported in 134 subjects (85%)